Publications

Publications

2024

• Hayes, T. K., E Aquilanti, N S. Persky, X Yang, E E. Kim, L Brenan, A B. Goodale, D Alan, T Sharpe, R E. Shue, L Westlake, L Golomb, B R. Silverman, M D. Morris, T Running Fisher, E Beyene, Y Y. Li, A D. Cherniack, F Piccioni, J. K Hicks, A S. Chi, D P. Cahill, J Dietrich, T T. Batchelor, D E. Root, C M. Johannessen & M Meyerson. Comprehensive mutational scanning of EGFR reveals TKI sensitivities of extracellular domain mutants. Nature Communications (Mar 28 2024) PMID: 38548752

2023

• Hayes, T. K., and M. Meyerson. Molecular Portraits of Lung Cancer Evolution. Nature 616, no. 7957 (Apr 12 2023): 435-36. PMID: 37045956

2021

• Waters, A. M., T. O. Khatib, B. Papke, C. M. Goodwin, G. A. Hobbs, J. N. Diehl, R. Yang, A. C. Edwards, K. H. Walsh, R. Sulahian, J. M. McFarland, K. S. Kapner, T. S. K. Gilbert, C. A. Stalnecker, S. Javaid, A. Barkovskaya, K. R. Grover, P. S. Hibshman, D. R. Blake, A. Schaefer, K. M. Nowak, J. E. Klomp, T. K. Hayes, M. Kassner, N. Tang, O. Tanaseichuk, K. Chen, Y. Zhou, M. Kalkat, L. E. Herring, L. M. Graves, L. Z. Penn, H. H. Yin, A. J. Aguirre, W. C. Hahn, A. D. Cox, and C. J. Der. Targeting P130cas- and Microtubule-Dependent Myc Regulation Sensitizes Pancreatic Cancer to Erk Mapk Inhibition. Cell Rep 35, no. 13 (Jun 29 2021): 109291. PMID: 34192548

2020

• Merad, M., A. D. Posey, Jr., O. Olivero, P. K. Singh, G. Mouneimne, L. Li, L. M. Wallace, and T. K. Hayes. Diversity Is a Strength of Cancer Research in the U.S. Cancer Cell 38, no. 3 (Sep 14 2020): 297-300. PMID: 32931736
• Tew, B. Y., J. K. Durand, K. L. Bryant, T. K. Hayes, S. Peng, N. L. Tran, G. C. Gooden, D. N. Buckley, C. J. Der, A. S. Baldwin, and B. Salhia. Genome-Wide DNA Methylation Analysis of Kras Mutant Cell Lines. Sci Rep 10, no. 1 (Jun 23 2020): 10149. PMID: 32576853
• Li, Y. C., N. K. Lytle, S. T. Gammon, L. Wang, T. K. Hayes, M. N. Sutton, R. C. Bast, Jr., C. J. Der, D. Piwnica-Worms, F. McCormick, and G. M. Wahl. Analysis of Ras Protein Interactions in Living Cells Reveals a Mechanism for Pan-Ras Depletion by Membrane-Targeted Ras Binders. Proc Natl Acad Sci U S A 117, no. 22 (Jun 2 2020): 12121-30. PMID: 32424096
• Persky, N. S., D. Hernandez, M. Do Carmo, L. Brenan, O. Cohen, S. Kitajima, U. Nayar, A. Walker, S. Pantel, Y. Lee, J. Cordova, M. Sathappa, C. Zhu, T. K. Hayes, P. Ram, P. Pancholi, T. S. Mikkelsen, D. A. Barbie, X. Yang, R. Haq, F. Piccioni, D. E. Root, and C. M. Johannessen. Defining the Landscape of Atp-Competitive Inhibitor Resistance Residues in Protein Kinases. Nat Struct Mol Biol 27, no. 1 (Jan 2020): 92-104. PMID: 31925410

2019

• Hayes, T. K., F. Luo, O. Cohen, A. B. Goodale, Y. Lee, S. Pantel, M. Bagul, F. Piccioni, D. E. Root, L. A. Garraway, M. Meyerson, and C. M. Johannessen. A Functional Landscape of Resistance to Mek1/2 and Cdk4/6 Inhibition in Nras-Mutant Melanoma. Cancer Res 79, no. 9 (May 1 2019): 2352-66. PMID: 30819666
• Bryant, K. L., C. A. Stalnecker, D. Zeitouni, J. E. Klomp, S. Peng, A. P. Tikunov, V. Gunda, M. Pierobon, A. M. Waters, S. D. George, G. Tomar, B. Papke, G. A. Hobbs, L. Yan, T. K. Hayes, J. N. Diehl, G. D. Goode, N. V. Chaika, Y. Wang, G. F. Zhang, A. K. Witkiewicz, E. S. Knudsen, E. F. Petricoin, 3rd, P. K. Singh, J. M. Macdonald, N. L. Tran, C. A. Lyssiotis, H. Ying, A. C. Kimmelman, A. D. Cox, and C. J. Der. Combination of Erk and Autophagy Inhibition as a Treatment Approach for Pancreatic Cancer. Nat Med 25, no. 4 (Apr 2019): 628-40. PMID: 30833752

2016 

• Hayes, T. K., N. F. Neel, C. Hu, P. Gautam, M. Chenard, B. Long, M. Aziz, M. Kassner, K. L. Bryant, M. Pierobon, R. Marayati, S. Kher, S. D. George, M. Xu, A. Wang-Gillam, A. A. Samatar, A. Maitra, K. Wennerberg, E. F. Petricoin, 3rd, H. H. Yin, B. Nelkin, A. D. Cox, J. J. Yeh, and C. J. Der. Long-Term Erk Inhibition in Kras-Mutant Pancreatic Cancer Is Associated with Myc Degradation and Senescence-Like Growth Suppression. Cancer Cell 29, no. 1 (Jan 11 2016): 75-89. PMID: 26725216

2014

• Putnam, C. D., K. Pallis, T. K. Hayes, and R. D. Kolodner. DNA Repair Pathway Selection Caused by Defects in Tel1, Sae2, and De Novo Telomere Addition Generates Specific Chromosomal Rearrangement Signatures. PLoS Genet 10, no. 4 (Apr 2014): e1004277. PMID: 24699249

2013

• Hayes, T. K. and C. J. Der. Mutant and Wild-Type Ras: Co-Conspirators in Cancer. Cancer Discov 3, no. 1 (Jan 2013): 24-6. PMID: 23319767

2012

• Putnam, C. D.,  S. R. Allen-Soltero, S. L. Martinez, J. E. Chan, T. K. Hayes, and R. D. Kolodner. Bioinformatic Identification of Genes Suppressing Genome Instability. Proc Natl Acad Sci U S A 109, no. 47 (Nov 20 2012): E3251-9. PMID: 23129647
• Neel, N. F., K. L. Rossman, T. D. Martin, T. K. Hayes, J. J. Yeh, and C. J. Der. The Ralb Small Gtpase Mediates Formation of Invadopodia through a Gtpase-Activating Protein-Independent Function of the Ralbp1/Rlip76 Effector. Mol Cell Biol 32, no. 8 (Apr 2012): 1374-86. PMID: 22331470

2010

• Putnam, C. D., T. K. Hayes, and R. D. Kolodner. Post-Replication Repair Suppresses Duplication-Mediated Genome Instability. PLoS Genet 6, no. 5 (May 6 2010): e1000933. PMID: 20463880

2009

• Wu, S., S. Vossius, S. Rahmouni, A. V. Miletic, T. Vang, J. Vazquez-Rodriguez, F. Cerignoli, Y. Arimura, S. Williams, T. Hayes, M. Moutschen, S. Vasile, M. Pellecchia, T. Mustelin, and L. Tautz. Multidentate Small-Molecule Inhibitors of Vaccinia H1-Related (Vhr) Phosphatase Decrease Proliferation of Cervix Cancer Cells. J Med Chem 52, no. 21 (Nov 12 2009): 6716-23. PMID: 19888758
• Putnam, C. D., T. K. Hayes, and R. D. Kolodner. Specific Pathways Prevent Duplication-Mediated Genome Rearrangements. Nature 460, no. 7258 (Aug 20 2009): 984-9. PMID: 19641493